Simulation of fixed sample size design for time-to-event endpoint
Source:R/sim_fixed_n.R
sim_fixed_n.Rdsim_fixed_n() provides simulations of a single endpoint two-arm trial
where the enrollment, hazard ratio, and failure and dropout rates change
over time.
Usage
sim_fixed_n(
n_sim = 1000,
sample_size = 500,
target_event = 350,
stratum = data.frame(stratum = "All", p = 1),
enroll_rate = data.frame(duration = c(2, 2, 10), rate = c(3, 6, 9)),
fail_rate = data.frame(stratum = "All", duration = c(3, 100), fail_rate = log(2)/c(9,
18), hr = c(0.9, 0.6), dropout_rate = rep(0.001, 2)),
total_duration = 30,
block = rep(c("experimental", "control"), 2),
timing_type = 1:5,
rho_gamma = data.frame(rho = 0, gamma = 0)
)Arguments
- n_sim
Number of simulations to perform.
- sample_size
Total sample size per simulation.
- target_event
Targeted event count for analysis.
- stratum
A data frame with stratum specified in
stratum, probability (incidence) of each stratum inp.- enroll_rate
Piecewise constant enrollment rates by time period. Note that these are overall population enrollment rates and the
stratumargument controls the random distribution between stratum.- fail_rate
Piecewise constant control group failure rates, hazard ratio for experimental vs. control, and dropout rates by stratum and time period.
- total_duration
Total follow-up from start of enrollment to data cutoff.
- block
As in
sim_pw_surv(). Vector of treatments to be included in each block.- timing_type
A numeric vector determining data cutoffs used; see details. Default is to include all available cutoff methods.
- rho_gamma
A data frame with variables
rhoandgamma, both greater than equal to zero, to specify one Fleming-Harrington weighted logrank test per row.
Value
A data frame including columns:
event: Event count.ln_hr: Log-hazard ratio.z: Normal test statistic; < 0 favors experimental.cut: Text describing cutoff used.duration: Duration of trial at cutoff for analysis.sim: Sequential simulation ID.
One row per simulated dataset per cutoff specified in timing_type,
per test statistic specified.
If multiple Fleming-Harrington tests are specified in rho_gamma,
then columns rho and gamma are also included.
Details
timing_type has up to 5 elements indicating different options
for data cutoff:
1: Uses the planned study duration.2: The time the targeted event count is achieved.3: The planned minimum follow-up after enrollment is complete.4: The maximum of planned study duration and targeted event count cuts (1 and 2).5: The maximum of targeted event count and minimum follow-up cuts (2 and 3).
Examples
library(dplyr)
library(future)
# Example 1: logrank test ----
x <- sim_fixed_n(n_sim = 10, timing_type = 1, rho_gamma = data.frame(rho = 0, gamma = 0))
#> Backend uses sequential processing.
# Get power approximation
mean(x$z <= qnorm(.025))
#> [1] 0
# Example 2: WLR with FH(0,1) ----
sim_fixed_n(n_sim = 1, timing_type = 1, rho_gamma = data.frame(rho = 0, gamma = 1))
#> Backend uses sequential processing.
#> method parameter estimate se z event ln_hr
#> 1 WLR FH(rho=0, gamma=1) -0.03587586 1.351219 0.02655074 103 -0.1042096
#> cut duration sim
#> 1 Planned duration 30 1
# Get power approximation
mean(x$z <= qnorm(.025))
#> [1] 0
# \donttest{
# Example 3: MaxCombo, i.e., WLR-FH(0,0)+ WLR-FH(0,1)
# Power by test
# Only use cuts for events, events + min follow-up
x <- sim_fixed_n(
n_sim = 10,
timing_type = 2,
rho_gamma = data.frame(rho = 0, gamma = c(0, 1))
)
#> Backend uses sequential processing.
# Get power approximation
x |>
group_by(sim) |>
filter(row_number() == 1) |>
ungroup() |>
summarize(power = mean(p_value < .025))
#> # A tibble: 1 × 1
#> power
#> <dbl>
#> 1 1
# Example 4
# Use two cores
set.seed(2023)
plan("multisession", workers = 2)
sim_fixed_n(n_sim = 10)
#> Using 2 cores with backend multisession
#> method parameter estimate se z event ln_hr
#> 1 WLR FH(rho=0, gamma=0) -9.044800 5.213492 1.7348832 109 -0.3342849
#> 2 WLR FH(rho=0, gamma=0) -41.170785 9.229540 4.4607622 350 -0.4793575
#> 3 WLR FH(rho=0, gamma=0) -41.444949 9.546994 4.3411518 376 -0.4498374
#> 4 WLR FH(rho=0, gamma=0) -41.170785 9.229540 4.4607622 350 -0.4793575
#> 5 WLR FH(rho=0, gamma=0) -41.444949 9.546994 4.3411518 376 -0.4498374
#> 6 WLR FH(rho=0, gamma=0) -5.248725 5.068148 1.0356297 103 -0.2047494
#> 7 WLR FH(rho=0, gamma=0) -33.266167 9.245312 3.5981660 350 -0.3873648
#> 8 WLR FH(rho=0, gamma=0) -35.663072 9.468334 3.7665623 367 -0.3953215
#> 9 WLR FH(rho=0, gamma=0) -33.266167 9.245312 3.5981660 350 -0.3873648
#> 10 WLR FH(rho=0, gamma=0) -35.663072 9.468334 3.7665623 367 -0.3953215
#> 11 WLR FH(rho=0, gamma=0) -18.821290 4.838510 3.8898935 95 -0.8181040
#> 12 WLR FH(rho=0, gamma=0) -55.442685 9.055033 6.1228581 350 -0.6662357
#> 13 WLR FH(rho=0, gamma=0) -55.753830 9.043216 6.1652657 349 -0.6719858
#> 14 WLR FH(rho=0, gamma=0) -55.442685 9.055033 6.1228581 350 -0.6662357
#> 15 WLR FH(rho=0, gamma=0) -55.442685 9.055033 6.1228581 350 -0.6662357
#> 16 WLR FH(rho=0, gamma=0) -3.064636 5.228765 0.5861109 110 -0.1120785
#> 17 WLR FH(rho=0, gamma=0) -33.961737 9.264232 3.6658988 350 -0.3939024
#> 18 WLR FH(rho=0, gamma=0) -34.607774 9.536543 3.6289642 372 -0.3781111
#> 19 WLR FH(rho=0, gamma=0) -33.961737 9.264232 3.6658988 350 -0.3939024
#> 20 WLR FH(rho=0, gamma=0) -34.607774 9.536543 3.6289642 372 -0.3781111
#> 21 WLR FH(rho=0, gamma=0) -13.960942 4.823458 2.8943845 94 -0.6069906
#> 22 WLR FH(rho=0, gamma=0) -37.851426 9.213540 4.1082391 350 -0.4410650
#> 23 WLR FH(rho=0, gamma=0) -36.640901 9.184545 3.9894083 348 -0.4296748
#> 24 WLR FH(rho=0, gamma=0) -37.851426 9.213540 4.1082391 350 -0.4410650
#> 25 WLR FH(rho=0, gamma=0) -37.851426 9.213540 4.1082391 350 -0.4410650
#> 26 WLR FH(rho=0, gamma=0) -14.173675 5.030231 2.8176983 103 -0.5638412
#> 27 WLR FH(rho=0, gamma=0) -35.792430 9.171024 3.9027737 350 -0.4227156
#> 28 WLR FH(rho=0, gamma=0) -36.093884 9.190638 3.9272445 351 -0.4245379
#> 29 WLR FH(rho=0, gamma=0) -35.792430 9.171024 3.9027737 350 -0.4227156
#> 30 WLR FH(rho=0, gamma=0) -36.093884 9.190638 3.9272445 351 -0.4245379
#> 31 WLR FH(rho=0, gamma=0) -4.479885 5.189040 0.8633360 108 -0.1666295
#> 32 WLR FH(rho=0, gamma=0) -29.984429 9.309267 3.2209226 350 -0.3453421
#> 33 WLR FH(rho=0, gamma=0) -27.732193 9.152805 3.0299119 338 -0.3305844
#> 34 WLR FH(rho=0, gamma=0) -29.984429 9.309267 3.2209226 350 -0.3453421
#> 35 WLR FH(rho=0, gamma=0) -29.984429 9.309267 3.2209226 350 -0.3453421
#> 36 WLR FH(rho=0, gamma=0) -8.620094 5.553024 1.5523243 124 -0.2803523
#> 37 WLR FH(rho=0, gamma=0) -30.211007 9.300647 3.2482694 350 -0.3478454
#> 38 WLR FH(rho=0, gamma=0) -33.581256 9.516244 3.5288351 367 -0.3690357
#> 39 WLR FH(rho=0, gamma=0) -30.211007 9.300647 3.2482694 350 -0.3478454
#> 40 WLR FH(rho=0, gamma=0) -33.581256 9.516244 3.5288351 367 -0.3690357
#> 41 WLR FH(rho=0, gamma=0) -3.955284 5.093447 0.7765436 104 -0.1525416
#> 42 WLR FH(rho=0, gamma=0) -26.670986 9.302656 2.8670291 350 -0.3069406
#> 43 WLR FH(rho=0, gamma=0) -26.342504 9.314768 2.8280363 351 -0.3023229
#> 44 WLR FH(rho=0, gamma=0) -26.670986 9.302656 2.8670291 350 -0.3069406
#> 45 WLR FH(rho=0, gamma=0) -26.342504 9.314768 2.8280363 351 -0.3023229
#> 46 WLR FH(rho=0, gamma=0) -9.242625 5.104900 1.8105400 106 -0.3551148
#> 47 WLR FH(rho=0, gamma=0) -35.255531 9.270632 3.8029263 350 -0.4077490
#> 48 WLR FH(rho=0, gamma=0) -36.706949 9.386743 3.9105095 360 -0.4138911
#> 49 WLR FH(rho=0, gamma=0) -35.255531 9.270632 3.8029263 350 -0.4077490
#> 50 WLR FH(rho=0, gamma=0) -36.706949 9.386743 3.9105095 360 -0.4138911
#> cut duration sim
#> 1 Planned duration 30.00000 1
#> 2 Targeted events 65.23187 1
#> 3 Minimum follow-up 73.17268 1
#> 4 Max(planned duration, event cut) 65.23187 1
#> 5 Max(min follow-up, event cut) 73.17268 1
#> 6 Planned duration 30.00000 2
#> 7 Targeted events 67.64612 2
#> 8 Minimum follow-up 72.56793 2
#> 9 Max(planned duration, event cut) 67.64612 2
#> 10 Max(min follow-up, event cut) 72.56793 2
#> 11 Planned duration 30.00000 3
#> 12 Targeted events 74.95821 3
#> 13 Minimum follow-up 74.72225 3
#> 14 Max(planned duration, event cut) 74.95821 3
#> 15 Max(min follow-up, event cut) 74.95821 3
#> 16 Planned duration 30.00000 4
#> 17 Targeted events 69.16631 4
#> 18 Minimum follow-up 73.68989 4
#> 19 Max(planned duration, event cut) 69.16631 4
#> 20 Max(min follow-up, event cut) 73.68989 4
#> 21 Planned duration 30.00000 5
#> 22 Targeted events 77.05035 5
#> 23 Minimum follow-up 76.68470 5
#> 24 Max(planned duration, event cut) 77.05035 5
#> 25 Max(min follow-up, event cut) 77.05035 5
#> 26 Planned duration 30.00000 6
#> 27 Targeted events 71.51268 6
#> 28 Minimum follow-up 72.34254 6
#> 29 Max(planned duration, event cut) 71.51268 6
#> 30 Max(min follow-up, event cut) 72.34254 6
#> 31 Planned duration 30.00000 7
#> 32 Targeted events 75.61250 7
#> 33 Minimum follow-up 72.99192 7
#> 34 Max(planned duration, event cut) 75.61250 7
#> 35 Max(min follow-up, event cut) 75.61250 7
#> 36 Planned duration 30.00000 8
#> 37 Targeted events 66.62160 8
#> 38 Minimum follow-up 70.19488 8
#> 39 Max(planned duration, event cut) 66.62160 8
#> 40 Max(min follow-up, event cut) 70.19488 8
#> 41 Planned duration 30.00000 9
#> 42 Targeted events 70.92746 9
#> 43 Minimum follow-up 71.28078 9
#> 44 Max(planned duration, event cut) 70.92746 9
#> 45 Max(min follow-up, event cut) 71.28078 9
#> 46 Planned duration 30.00000 10
#> 47 Targeted events 75.17856 10
#> 48 Minimum follow-up 76.94235 10
#> 49 Max(planned duration, event cut) 75.17856 10
#> 50 Max(min follow-up, event cut) 76.94235 10
plan("sequential")
# Example 5: Stratified design with two strata
sim_fixed_n(
n_sim = 100,
sample_size = 500,
target_event = 350,
stratum = data.frame(stratum = c("Biomarker-positive", "Biomarker-negative"),
p = c(0.5, 0.5)),
enroll_rate = data.frame(stratum = c("Biomarker positive", "Biomarker negative"),
duration = c(12, 12), rate = c(250 / 12, 250 / 12)),
fail_rate = data.frame(stratum = c(rep("Biomarker-positive", 2), rep("Biomarker-negative", 2)),
duration = c(3, Inf, 3, Inf),
fail_rate = log(2) / c(12, 12, 8, 8),
hr = c(1, 0.6, 1, 0.7),
dropout_rate = rep(0.001, 4)),
total_duration = 30,
block = rep(c("experimental", "control"), 2),
timing_type = 1:5,
rho_gamma = data.frame(rho = 0, gamma = 0)
)
#> Backend uses sequential processing.
#> method parameter estimate se z event ln_hr
#> 1 WLR FH(rho=0, gamma=0) -23.0217533 8.752762 2.6302274 310 -0.30029344
#> 2 WLR FH(rho=0, gamma=0) -28.3774965 9.310166 3.0480120 350 -0.32682864
#> 3 WLR FH(rho=0, gamma=0) -23.9658317 8.782125 2.7289330 312 -0.31062740
#> 4 WLR FH(rho=0, gamma=0) -28.3774965 9.310166 3.0480120 350 -0.32682864
#> 5 WLR FH(rho=0, gamma=0) -28.3774965 9.310166 3.0480120 350 -0.32682864
#> 6 WLR FH(rho=0, gamma=0) -28.0378878 9.106595 3.0788551 341 -0.33645614
#> 7 WLR FH(rho=0, gamma=0) -27.8651365 9.215376 3.0237657 350 -0.32623754
#> 8 WLR FH(rho=0, gamma=0) -29.4918973 9.128929 3.2305978 343 -0.35213216
#> 9 WLR FH(rho=0, gamma=0) -27.8651365 9.215376 3.0237657 350 -0.32623754
#> 10 WLR FH(rho=0, gamma=0) -27.8651365 9.215376 3.0237657 350 -0.32623754
#> 11 WLR FH(rho=0, gamma=0) -19.9895259 8.582706 2.3290471 299 -0.27024389
#> 12 WLR FH(rho=0, gamma=0) -28.6984044 9.269404 3.0960355 350 -0.33262732
#> 13 WLR FH(rho=0, gamma=0) -22.9794888 8.798074 2.6118772 314 -0.29572618
#> 14 WLR FH(rho=0, gamma=0) -28.6984044 9.269404 3.0960355 350 -0.33262732
#> 15 WLR FH(rho=0, gamma=0) -28.6984044 9.269404 3.0960355 350 -0.33262732
#> 16 WLR FH(rho=0, gamma=0) -15.5450643 8.594257 1.8087735 300 -0.21024615
#> 17 WLR FH(rho=0, gamma=0) -20.9736871 9.267135 2.2632333 350 -0.24370326
#> 18 WLR FH(rho=0, gamma=0) -14.4459088 8.566737 1.6862790 298 -0.19661125
#> 19 WLR FH(rho=0, gamma=0) -20.9736871 9.267135 2.2632333 350 -0.24370326
#> 20 WLR FH(rho=0, gamma=0) -20.9736871 9.267135 2.2632333 350 -0.24370326
#> 21 WLR FH(rho=0, gamma=0) -35.7298623 8.956037 3.9894724 327 -0.44296572
#> 22 WLR FH(rho=0, gamma=0) -36.7020825 9.254444 3.9658873 350 -0.42531116
#> 23 WLR FH(rho=0, gamma=0) -33.0845277 8.779541 3.7683664 314 -0.42699651
#> 24 WLR FH(rho=0, gamma=0) -36.7020825 9.254444 3.9658873 350 -0.42531116
#> 25 WLR FH(rho=0, gamma=0) -36.7020825 9.254444 3.9658873 350 -0.42531116
#> 26 WLR FH(rho=0, gamma=0) -17.8702596 8.406896 2.1256668 290 -0.25207459
#> 27 WLR FH(rho=0, gamma=0) -23.6940561 9.255954 2.5598719 350 -0.27574411
#> 28 WLR FH(rho=0, gamma=0) -19.0565166 8.522547 2.2360118 298 -0.26159419
#> 29 WLR FH(rho=0, gamma=0) -23.6940561 9.255954 2.5598719 350 -0.27574411
#> 30 WLR FH(rho=0, gamma=0) -23.6940561 9.255954 2.5598719 350 -0.27574411
#> 31 WLR FH(rho=0, gamma=0) -7.0509413 9.054989 0.7786803 330 -0.08604742
#> 32 WLR FH(rho=0, gamma=0) -11.8554453 9.293781 1.2756321 350 -0.13742953
#> 33 WLR FH(rho=0, gamma=0) -6.5424439 8.878172 0.7369134 317 -0.08307238
#> 34 WLR FH(rho=0, gamma=0) -11.8554453 9.293781 1.2756321 350 -0.13742953
#> 35 WLR FH(rho=0, gamma=0) -11.8554453 9.293781 1.2756321 350 -0.13742953
#> 36 WLR FH(rho=0, gamma=0) -34.8234744 8.872071 3.9250672 323 -0.43866266
#> 37 WLR FH(rho=0, gamma=0) -34.7614655 9.230537 3.7659201 350 -0.40440234
#> 38 WLR FH(rho=0, gamma=0) -34.6324995 9.004425 3.8461644 333 -0.42332034
#> 39 WLR FH(rho=0, gamma=0) -34.7614655 9.230537 3.7659201 350 -0.40440234
#> 40 WLR FH(rho=0, gamma=0) -34.7614655 9.230537 3.7659201 350 -0.40440234
#> 41 WLR FH(rho=0, gamma=0) -30.7475093 8.820932 3.4857440 317 -0.39446809
#> 42 WLR FH(rho=0, gamma=0) -33.5914493 9.255431 3.6293770 350 -0.39043498
#> 43 WLR FH(rho=0, gamma=0) -30.0602424 8.778702 3.4242240 314 -0.38934144
#> 44 WLR FH(rho=0, gamma=0) -33.5914493 9.255431 3.6293770 350 -0.39043498
#> 45 WLR FH(rho=0, gamma=0) -33.5914493 9.255431 3.6293770 350 -0.39043498
#> 46 WLR FH(rho=0, gamma=0) -27.3641388 8.796324 3.1108606 312 -0.35560770
#> 47 WLR FH(rho=0, gamma=0) -31.5174359 9.281577 3.3956984 350 -0.36638432
#> 48 WLR FH(rho=0, gamma=0) -23.0716170 8.627495 2.6741964 300 -0.31148253
#> 49 WLR FH(rho=0, gamma=0) -31.5174359 9.281577 3.3956984 350 -0.36638432
#> 50 WLR FH(rho=0, gamma=0) -31.5174359 9.281577 3.3956984 350 -0.36638432
#> 51 WLR FH(rho=0, gamma=0) -30.9110110 8.730481 3.5405852 311 -0.40528560
#> 52 WLR FH(rho=0, gamma=0) -35.2405945 9.232274 3.8171086 350 -0.41168005
#> 53 WLR FH(rho=0, gamma=0) -29.0115844 8.632358 3.3607947 304 -0.38895635
#> 54 WLR FH(rho=0, gamma=0) -35.2405945 9.232274 3.8171086 350 -0.41168005
#> 55 WLR FH(rho=0, gamma=0) -35.2405945 9.232274 3.8171086 350 -0.41168005
#> 56 WLR FH(rho=0, gamma=0) -48.1321495 8.975568 5.3625744 334 -0.59244381
#> 57 WLR FH(rho=0, gamma=0) -50.3345007 9.160127 5.4949564 350 -0.59276243
#> 58 WLR FH(rho=0, gamma=0) -47.0829895 8.938771 5.2672775 331 -0.58452939
#> 59 WLR FH(rho=0, gamma=0) -50.3345007 9.160127 5.4949564 350 -0.59276243
#> 60 WLR FH(rho=0, gamma=0) -50.3345007 9.160127 5.4949564 350 -0.59276243
#> 61 WLR FH(rho=0, gamma=0) -43.3785589 9.052589 4.7918401 338 -0.52675920
#> 62 WLR FH(rho=0, gamma=0) -42.3918526 9.196295 4.6096662 350 -0.49750894
#> 63 WLR FH(rho=0, gamma=0) -40.8963942 8.928079 4.5806489 328 -0.51102684
#> 64 WLR FH(rho=0, gamma=0) -42.3918526 9.196295 4.6096662 350 -0.49750894
#> 65 WLR FH(rho=0, gamma=0) -42.3918526 9.196295 4.6096662 350 -0.49750894
#> 66 WLR FH(rho=0, gamma=0) -12.5335612 8.270098 1.5155274 275 -0.18303258
#> 67 WLR FH(rho=0, gamma=0) -25.7711264 9.287901 2.7746988 350 -0.29838922
#> 68 WLR FH(rho=0, gamma=0) -21.3248269 8.962848 2.3792467 324 -0.26522039
#> 69 WLR FH(rho=0, gamma=0) -25.7711264 9.287901 2.7746988 350 -0.29838922
#> 70 WLR FH(rho=0, gamma=0) -25.7711264 9.287901 2.7746988 350 -0.29838922
#> 71 WLR FH(rho=0, gamma=0) -23.7379517 8.651410 2.7438247 304 -0.31632293
#> 72 WLR FH(rho=0, gamma=0) -31.6025706 9.269531 3.4092955 350 -0.36635582
#> 73 WLR FH(rho=0, gamma=0) -23.9287643 8.680196 2.7567079 306 -0.31670472
#> 74 WLR FH(rho=0, gamma=0) -31.6025706 9.269531 3.4092955 350 -0.36635582
#> 75 WLR FH(rho=0, gamma=0) -31.6025706 9.269531 3.4092955 350 -0.36635582
#> 76 WLR FH(rho=0, gamma=0) -31.4735337 8.849698 3.5564529 318 -0.40052914
#> 77 WLR FH(rho=0, gamma=0) -34.7754312 9.272737 3.7502876 350 -0.40214354
#> 78 WLR FH(rho=0, gamma=0) -30.3728310 8.819829 3.4436985 316 -0.38907085
#> 79 WLR FH(rho=0, gamma=0) -34.7754312 9.272737 3.7502876 350 -0.40214354
#> 80 WLR FH(rho=0, gamma=0) -34.7754312 9.272737 3.7502876 350 -0.40214354
#> 81 WLR FH(rho=0, gamma=0) -27.8521453 8.619937 3.2311308 303 -0.37311943
#> 82 WLR FH(rho=0, gamma=0) -32.4552759 9.256665 3.5061522 350 -0.37629234
#> 83 WLR FH(rho=0, gamma=0) -28.7017380 8.697853 3.2998645 308 -0.37761899
#> 84 WLR FH(rho=0, gamma=0) -32.4552759 9.256665 3.5061522 350 -0.37629234
#> 85 WLR FH(rho=0, gamma=0) -32.4552759 9.256665 3.5061522 350 -0.37629234
#> 86 WLR FH(rho=0, gamma=0) -26.7882229 8.972136 2.9857129 327 -0.33405231
#> 87 WLR FH(rho=0, gamma=0) -25.8232049 9.266517 2.7867219 350 -0.30097164
#> 88 WLR FH(rho=0, gamma=0) -21.7179990 8.732339 2.4870771 308 -0.28592107
#> 89 WLR FH(rho=0, gamma=0) -25.8232049 9.266517 2.7867219 350 -0.30097164
#> 90 WLR FH(rho=0, gamma=0) -25.8232049 9.266517 2.7867219 350 -0.30097164
#> 91 WLR FH(rho=0, gamma=0) -16.6543596 8.768618 1.8993141 311 -0.21624668
#> 92 WLR FH(rho=0, gamma=0) -16.8725446 9.295078 1.8152127 350 -0.19475083
#> 93 WLR FH(rho=0, gamma=0) -15.0244100 8.637306 1.7394787 302 -0.20102561
#> 94 WLR FH(rho=0, gamma=0) -16.8725446 9.295078 1.8152127 350 -0.19475083
#> 95 WLR FH(rho=0, gamma=0) -16.8725446 9.295078 1.8152127 350 -0.19475083
#> 96 WLR FH(rho=0, gamma=0) -16.2918506 8.721234 1.8680671 306 -0.21449591
#> 97 WLR FH(rho=0, gamma=0) -17.9933565 9.322070 1.9301889 350 -0.20706120
#> 98 WLR FH(rho=0, gamma=0) -16.9317973 8.737864 1.9377502 307 -0.22211137
#> 99 WLR FH(rho=0, gamma=0) -17.9933565 9.322070 1.9301889 350 -0.20706120
#> 100 WLR FH(rho=0, gamma=0) -17.9933565 9.322070 1.9301889 350 -0.20706120
#> 101 WLR FH(rho=0, gamma=0) -10.3222660 9.197303 1.1223144 339 -0.12209815
#> 102 WLR FH(rho=0, gamma=0) -9.8780180 9.337959 1.0578348 350 -0.11330337
#> 103 WLR FH(rho=0, gamma=0) -10.9492989 9.209522 1.1889107 340 -0.12918058
#> 104 WLR FH(rho=0, gamma=0) -9.8780180 9.337959 1.0578348 350 -0.11330337
#> 105 WLR FH(rho=0, gamma=0) -9.8780180 9.337959 1.0578348 350 -0.11330337
#> 106 WLR FH(rho=0, gamma=0) -32.5747303 8.786658 3.7072945 313 -0.42076185
#> 107 WLR FH(rho=0, gamma=0) -35.0635997 9.270084 3.7824467 350 -0.40562808
#> 108 WLR FH(rho=0, gamma=0) -31.8178125 8.561311 3.7164652 297 -0.43382629
#> 109 WLR FH(rho=0, gamma=0) -35.0635997 9.270084 3.7824467 350 -0.40562808
#> 110 WLR FH(rho=0, gamma=0) -35.0635997 9.270084 3.7824467 350 -0.40562808
#> 111 WLR FH(rho=0, gamma=0) -23.6761482 8.838287 2.6788165 318 -0.30253223
#> 112 WLR FH(rho=0, gamma=0) -29.9395274 9.248777 3.2371335 350 -0.34904631
#> 113 WLR FH(rho=0, gamma=0) -23.3343687 8.783025 2.6567575 313 -0.30198262
#> 114 WLR FH(rho=0, gamma=0) -29.9395274 9.248777 3.2371335 350 -0.34904631
#> 115 WLR FH(rho=0, gamma=0) -29.9395274 9.248777 3.2371335 350 -0.34904631
#> 116 WLR FH(rho=0, gamma=0) -36.8192707 8.749726 4.2080484 311 -0.48027125
#> 117 WLR FH(rho=0, gamma=0) -39.7294708 9.221951 4.3081417 350 -0.46378294
#> 118 WLR FH(rho=0, gamma=0) -35.9586301 8.739532 4.1144801 310 -0.47019131
#> 119 WLR FH(rho=0, gamma=0) -39.7294708 9.221951 4.3081417 350 -0.46378294
#> 120 WLR FH(rho=0, gamma=0) -39.7294708 9.221951 4.3081417 350 -0.46378294
#> 121 WLR FH(rho=0, gamma=0) -21.4168275 8.697338 2.4624578 309 -0.28261292
#> 122 WLR FH(rho=0, gamma=0) -20.8402767 9.256274 2.2514757 350 -0.24256953
#> 123 WLR FH(rho=0, gamma=0) -20.4934076 8.880617 2.3076558 323 -0.25921566
#> 124 WLR FH(rho=0, gamma=0) -20.8402767 9.256274 2.2514757 350 -0.24256953
#> 125 WLR FH(rho=0, gamma=0) -20.8402767 9.256274 2.2514757 350 -0.24256953
#> 126 WLR FH(rho=0, gamma=0) -33.9208613 8.812044 3.8493747 321 -0.43446252
#> 127 WLR FH(rho=0, gamma=0) -38.7123697 9.189954 4.2124662 350 -0.45503180
#> 128 WLR FH(rho=0, gamma=0) -32.7488326 8.778258 3.7306756 319 -0.42282777
#> 129 WLR FH(rho=0, gamma=0) -38.7123697 9.189954 4.2124662 350 -0.45503180
#> 130 WLR FH(rho=0, gamma=0) -38.7123697 9.189954 4.2124662 350 -0.45503180
#> 131 WLR FH(rho=0, gamma=0) -18.9542631 8.774471 2.1601602 313 -0.24548953
#> 132 WLR FH(rho=0, gamma=0) -19.8637821 9.277379 2.1410984 350 -0.23012157
#> 133 WLR FH(rho=0, gamma=0) -17.3763188 8.847982 1.9638737 318 -0.22132427
#> 134 WLR FH(rho=0, gamma=0) -19.8637821 9.277379 2.1410984 350 -0.23012157
#> 135 WLR FH(rho=0, gamma=0) -19.8637821 9.277379 2.1410984 350 -0.23012157
#> 136 WLR FH(rho=0, gamma=0) -16.7068083 8.785587 1.9016155 310 -0.21658268
#> 137 WLR FH(rho=0, gamma=0) -17.0994488 9.332407 1.8322657 350 -0.19618393
#> 138 WLR FH(rho=0, gamma=0) -17.6929966 8.855848 1.9978885 315 -0.22572172
#> 139 WLR FH(rho=0, gamma=0) -17.0994488 9.332407 1.8322657 350 -0.19618393
#> 140 WLR FH(rho=0, gamma=0) -17.0994488 9.332407 1.8322657 350 -0.19618393
#> 141 WLR FH(rho=0, gamma=0) -42.3336521 9.010366 4.6983277 336 -0.51718957
#> 142 WLR FH(rho=0, gamma=0) -40.3371501 9.186875 4.3907368 350 -0.47372737
#> 143 WLR FH(rho=0, gamma=0) -41.6927465 8.841731 4.7154506 324 -0.52913913
#> 144 WLR FH(rho=0, gamma=0) -40.3371501 9.186875 4.3907368 350 -0.47372737
#> 145 WLR FH(rho=0, gamma=0) -40.3371501 9.186875 4.3907368 350 -0.47372737
#> 146 WLR FH(rho=0, gamma=0) -19.4878321 8.581649 2.2708728 300 -0.26428285
#> 147 WLR FH(rho=0, gamma=0) -26.7739246 9.297486 2.8796949 350 -0.30871866
#> 148 WLR FH(rho=0, gamma=0) -22.0266202 8.770713 2.5113832 311 -0.28600656
#> 149 WLR FH(rho=0, gamma=0) -26.7739246 9.297486 2.8796949 350 -0.30871866
#> 150 WLR FH(rho=0, gamma=0) -26.7739246 9.297486 2.8796949 350 -0.30871866
#> 151 WLR FH(rho=0, gamma=0) -8.9493826 8.756184 1.0220642 308 -0.11668833
#> 152 WLR FH(rho=0, gamma=0) -17.6073833 9.327134 1.8877592 350 -0.20232370
#> 153 WLR FH(rho=0, gamma=0) -7.9334211 8.712405 0.9105891 305 -0.10448944
#> 154 WLR FH(rho=0, gamma=0) -17.6073833 9.327134 1.8877592 350 -0.20232370
#> 155 WLR FH(rho=0, gamma=0) -17.6073833 9.327134 1.8877592 350 -0.20232370
#> 156 WLR FH(rho=0, gamma=0) -17.7307987 8.544000 2.0752338 296 -0.24280771
#> 157 WLR FH(rho=0, gamma=0) -27.0152820 9.253341 2.9195165 350 -0.31498273
#> 158 WLR FH(rho=0, gamma=0) -22.3734300 8.691050 2.5743068 307 -0.29624047
#> 159 WLR FH(rho=0, gamma=0) -27.0152820 9.253341 2.9195165 350 -0.31498273
#> 160 WLR FH(rho=0, gamma=0) -27.0152820 9.253341 2.9195165 350 -0.31498273
#> 161 WLR FH(rho=0, gamma=0) -32.8696136 8.733455 3.7636438 312 -0.42771575
#> 162 WLR FH(rho=0, gamma=0) -37.5057092 9.213586 4.0706960 350 -0.43770216
#> 163 WLR FH(rho=0, gamma=0) -31.0132488 8.657688 3.5821630 306 -0.41076403
#> 164 WLR FH(rho=0, gamma=0) -37.5057092 9.213586 4.0706960 350 -0.43770216
#> 165 WLR FH(rho=0, gamma=0) -37.5057092 9.213586 4.0706960 350 -0.43770216
#> 166 WLR FH(rho=0, gamma=0) -33.6201811 8.820126 3.8117573 320 -0.43057178
#> 167 WLR FH(rho=0, gamma=0) -36.6146514 9.211397 3.9749291 350 -0.42909823
#> 168 WLR FH(rho=0, gamma=0) -31.4428565 8.726440 3.6031713 313 -0.41136245
#> 169 WLR FH(rho=0, gamma=0) -36.6146514 9.211397 3.9749291 350 -0.42909823
#> 170 WLR FH(rho=0, gamma=0) -36.6146514 9.211397 3.9749291 350 -0.42909823
#> 171 WLR FH(rho=0, gamma=0) -22.3080122 8.777709 2.5414390 312 -0.28985841
#> 172 WLR FH(rho=0, gamma=0) -29.0214100 9.315037 3.1155442 350 -0.33437028
#> 173 WLR FH(rho=0, gamma=0) -22.7393646 8.761924 2.5952480 310 -0.29661595
#> 174 WLR FH(rho=0, gamma=0) -29.0214100 9.315037 3.1155442 350 -0.33437028
#> 175 WLR FH(rho=0, gamma=0) -29.0214100 9.315037 3.1155442 350 -0.33437028
#> 176 WLR FH(rho=0, gamma=0) -30.5296970 9.054633 3.3717210 332 -0.37017877
#> 177 WLR FH(rho=0, gamma=0) -35.3351810 9.287386 3.8046422 350 -0.40703285
#> 178 WLR FH(rho=0, gamma=0) -25.5615987 8.507535 3.0045834 294 -0.35127341
#> 179 WLR FH(rho=0, gamma=0) -35.3351810 9.287386 3.8046422 350 -0.40703285
#> 180 WLR FH(rho=0, gamma=0) -35.3351810 9.287386 3.8046422 350 -0.40703285
#> 181 WLR FH(rho=0, gamma=0) -32.0886727 8.799964 3.6464551 315 -0.41235825
#> 182 WLR FH(rho=0, gamma=0) -38.8362794 9.248536 4.1991813 350 -0.45084618
#> 183 WLR FH(rho=0, gamma=0) -28.3268145 8.621840 3.2854719 302 -0.37925699
#> 184 WLR FH(rho=0, gamma=0) -38.8362794 9.248536 4.1991813 350 -0.45084618
#> 185 WLR FH(rho=0, gamma=0) -38.8362794 9.248536 4.1991813 350 -0.45084618
#> 186 WLR FH(rho=0, gamma=0) -36.5715225 8.884521 4.1163188 321 -0.46286662
#> 187 WLR FH(rho=0, gamma=0) -37.2892180 9.249808 4.0313505 350 -0.43341309
#> 188 WLR FH(rho=0, gamma=0) -33.2374803 8.677885 3.8301363 305 -0.44166833
#> 189 WLR FH(rho=0, gamma=0) -37.2892180 9.249808 4.0313505 350 -0.43341309
#> 190 WLR FH(rho=0, gamma=0) -37.2892180 9.249808 4.0313505 350 -0.43341309
#> 191 WLR FH(rho=0, gamma=0) -12.4186226 8.743398 1.4203428 309 -0.16241111
#> 192 WLR FH(rho=0, gamma=0) -12.7622574 9.302922 1.3718548 350 -0.14735013
#> 193 WLR FH(rho=0, gamma=0) -12.4266822 8.743426 1.4212601 309 -0.16251495
#> 194 WLR FH(rho=0, gamma=0) -12.7622574 9.302922 1.3718548 350 -0.14735013
#> 195 WLR FH(rho=0, gamma=0) -12.7622574 9.302922 1.3718548 350 -0.14735013
#> 196 WLR FH(rho=0, gamma=0) -15.5849030 8.585032 1.8153576 299 -0.21109104
#> 197 WLR FH(rho=0, gamma=0) -18.7307870 9.273230 2.0198774 350 -0.21733600
#> 198 WLR FH(rho=0, gamma=0) -16.8363504 8.786618 1.9161355 313 -0.21772362
#> 199 WLR FH(rho=0, gamma=0) -18.7307870 9.273230 2.0198774 350 -0.21733600
#> 200 WLR FH(rho=0, gamma=0) -18.7307870 9.273230 2.0198774 350 -0.21733600
#> 201 WLR FH(rho=0, gamma=0) -15.6966139 8.664844 1.8115287 306 -0.20903061
#> 202 WLR FH(rho=0, gamma=0) -24.4305155 9.281455 2.6321860 350 -0.28375303
#> 203 WLR FH(rho=0, gamma=0) -20.5865948 8.932866 2.3045902 325 -0.25819613
#> 204 WLR FH(rho=0, gamma=0) -24.4305155 9.281455 2.6321860 350 -0.28375303
#> 205 WLR FH(rho=0, gamma=0) -24.4305155 9.281455 2.6321860 350 -0.28375303
#> 206 WLR FH(rho=0, gamma=0) -24.3701211 8.919225 2.7323138 323 -0.30695753
#> 207 WLR FH(rho=0, gamma=0) -25.8468992 9.271371 2.7878186 350 -0.30055863
#> 208 WLR FH(rho=0, gamma=0) -19.7051091 8.594537 2.2927482 299 -0.26725365
#> 209 WLR FH(rho=0, gamma=0) -25.8468992 9.271371 2.7878186 350 -0.30055863
#> 210 WLR FH(rho=0, gamma=0) -25.8468992 9.271371 2.7878186 350 -0.30055863
#> 211 WLR FH(rho=0, gamma=0) -20.7703108 8.896869 2.3345641 320 -0.26207417
#> 212 WLR FH(rho=0, gamma=0) -23.0593264 9.294166 2.4810540 350 -0.26635387
#> 213 WLR FH(rho=0, gamma=0) -20.4188140 8.873175 2.3011847 318 -0.25905764
#> 214 WLR FH(rho=0, gamma=0) -23.0593264 9.294166 2.4810540 350 -0.26635387
#> 215 WLR FH(rho=0, gamma=0) -23.0593264 9.294166 2.4810540 350 -0.26635387
#> 216 WLR FH(rho=0, gamma=0) -9.4581381 8.675215 1.0902482 302 -0.12571247
#> 217 WLR FH(rho=0, gamma=0) -11.9191983 9.341722 1.2759102 350 -0.13658592
#> 218 WLR FH(rho=0, gamma=0) -9.8116987 8.949088 1.0963909 321 -0.12255923
#> 219 WLR FH(rho=0, gamma=0) -11.9191983 9.341722 1.2759102 350 -0.13658592
#> 220 WLR FH(rho=0, gamma=0) -11.9191983 9.341722 1.2759102 350 -0.13658592
#> 221 WLR FH(rho=0, gamma=0) -24.2655590 8.766301 2.7680499 313 -0.31544161
#> 222 WLR FH(rho=0, gamma=0) -30.0543959 9.248263 3.2497341 350 -0.35064277
#> 223 WLR FH(rho=0, gamma=0) -25.6011591 9.038467 2.8324669 333 -0.31283343
#> 224 WLR FH(rho=0, gamma=0) -30.0543959 9.248263 3.2497341 350 -0.35064277
#> 225 WLR FH(rho=0, gamma=0) -30.0543959 9.248263 3.2497341 350 -0.35064277
#> 226 WLR FH(rho=0, gamma=0) -6.1156459 8.794579 0.6953881 311 -0.07912088
#> 227 WLR FH(rho=0, gamma=0) -4.9280980 9.284472 0.5307893 350 -0.05718337
#> 228 WLR FH(rho=0, gamma=0) -5.5638383 8.877137 0.6267604 317 -0.07063383
#> 229 WLR FH(rho=0, gamma=0) -4.9280980 9.284472 0.5307893 350 -0.05718337
#> 230 WLR FH(rho=0, gamma=0) -4.9280980 9.284472 0.5307893 350 -0.05718337
#> 231 WLR FH(rho=0, gamma=0) -24.9842532 8.648498 2.8888546 305 -0.33277908
#> 232 WLR FH(rho=0, gamma=0) -25.5842772 9.211499 2.7774281 350 -0.29976797
#> 233 WLR FH(rho=0, gamma=0) -25.0610595 8.645572 2.8987162 305 -0.33402892
#> 234 WLR FH(rho=0, gamma=0) -25.5842772 9.211499 2.7774281 350 -0.29976797
#> 235 WLR FH(rho=0, gamma=0) -25.5842772 9.211499 2.7774281 350 -0.29976797
#> 236 WLR FH(rho=0, gamma=0) -17.1997266 8.899854 1.9325854 320 -0.21716388
#> 237 WLR FH(rho=0, gamma=0) -19.5160802 9.305537 2.0972547 350 -0.22523687
#> 238 WLR FH(rho=0, gamma=0) -17.1671691 8.899786 1.9289417 320 -0.21675942
#> 239 WLR FH(rho=0, gamma=0) -19.5160802 9.305537 2.0972547 350 -0.22523687
#> 240 WLR FH(rho=0, gamma=0) -19.5160802 9.305537 2.0972547 350 -0.22523687
#> 241 WLR FH(rho=0, gamma=0) -10.0772762 8.816377 1.1430178 314 -0.12962775
#> 242 WLR FH(rho=0, gamma=0) -13.5566199 9.311732 1.4558645 350 -0.15629940
#> 243 WLR FH(rho=0, gamma=0) -11.8291282 8.674211 1.3637123 304 -0.15725195
#> 244 WLR FH(rho=0, gamma=0) -13.5566199 9.311732 1.4558645 350 -0.15629940
#> 245 WLR FH(rho=0, gamma=0) -13.5566199 9.311732 1.4558645 350 -0.15629940
#> 246 WLR FH(rho=0, gamma=0) -9.9498381 8.727932 1.1399995 306 -0.13068069
#> 247 WLR FH(rho=0, gamma=0) -18.0787069 9.325042 1.9387265 350 -0.20807877
#> 248 WLR FH(rho=0, gamma=0) -9.8474647 8.889298 1.1077888 317 -0.12466322
#> 249 WLR FH(rho=0, gamma=0) -18.0787069 9.325042 1.9387265 350 -0.20807877
#> 250 WLR FH(rho=0, gamma=0) -18.0787069 9.325042 1.9387265 350 -0.20807877
#> 251 WLR FH(rho=0, gamma=0) -27.5142853 8.743322 3.1468916 308 -0.36023023
#> 252 WLR FH(rho=0, gamma=0) -28.0374941 9.292246 3.0173000 350 -0.32369504
#> 253 WLR FH(rho=0, gamma=0) -28.3328345 8.813664 3.2146488 313 -0.36502686
#> 254 WLR FH(rho=0, gamma=0) -28.0374941 9.292246 3.0173000 350 -0.32369504
#> 255 WLR FH(rho=0, gamma=0) -28.0374941 9.292246 3.0173000 350 -0.32369504
#> 256 WLR FH(rho=0, gamma=0) -0.9220231 8.860248 0.1040629 315 -0.01174531
#> 257 WLR FH(rho=0, gamma=0) -6.3006438 9.336686 0.6748266 350 -0.07230410
#> 258 WLR FH(rho=0, gamma=0) -2.9711679 9.055844 0.3280940 329 -0.03623614
#> 259 WLR FH(rho=0, gamma=0) -6.3006438 9.336686 0.6748266 350 -0.07230410
#> 260 WLR FH(rho=0, gamma=0) -6.3006438 9.336686 0.6748266 350 -0.07230410
#> 261 WLR FH(rho=0, gamma=0) -15.8778352 8.829094 1.7983539 314 -0.20364340
#> 262 WLR FH(rho=0, gamma=0) -24.3996969 9.288402 2.6268994 350 -0.28274960
#> 263 WLR FH(rho=0, gamma=0) -18.1370497 8.976176 2.0205763 325 -0.22507115
#> 264 WLR FH(rho=0, gamma=0) -24.3996969 9.288402 2.6268994 350 -0.28274960
#> 265 WLR FH(rho=0, gamma=0) -24.3996969 9.288402 2.6268994 350 -0.28274960
#> 266 WLR FH(rho=0, gamma=0) -19.2808119 8.662191 2.2258585 305 -0.25739330
#> 267 WLR FH(rho=0, gamma=0) -24.0832111 9.287617 2.5930452 350 -0.27908474
#> 268 WLR FH(rho=0, gamma=0) -18.9093948 8.837163 2.1397584 318 -0.24228978
#> 269 WLR FH(rho=0, gamma=0) -24.0832111 9.287617 2.5930452 350 -0.27908474
#> 270 WLR FH(rho=0, gamma=0) -24.0832111 9.287617 2.5930452 350 -0.27908474
#> 271 WLR FH(rho=0, gamma=0) -22.1900697 8.855518 2.5057901 321 -0.28287832
#> 272 WLR FH(rho=0, gamma=0) -25.8986315 9.244533 2.8015079 350 -0.30299889
#> 273 WLR FH(rho=0, gamma=0) -22.8636630 8.897950 2.5695428 324 -0.28869416
#> 274 WLR FH(rho=0, gamma=0) -25.8986315 9.244533 2.8015079 350 -0.30299889
#> 275 WLR FH(rho=0, gamma=0) -25.8986315 9.244533 2.8015079 350 -0.30299889
#> 276 WLR FH(rho=0, gamma=0) -20.8540097 9.076966 2.2974648 335 -0.25280041
#> 277 WLR FH(rho=0, gamma=0) -19.4027897 9.261272 2.0950458 350 -0.22584098
#> 278 WLR FH(rho=0, gamma=0) -17.5286071 8.935616 1.9616563 324 -0.21922321
#> 279 WLR FH(rho=0, gamma=0) -19.4027897 9.261272 2.0950458 350 -0.22584098
#> 280 WLR FH(rho=0, gamma=0) -19.4027897 9.261272 2.0950458 350 -0.22584098
#> 281 WLR FH(rho=0, gamma=0) -23.6000777 8.609437 2.7411871 300 -0.31788291
#> 282 WLR FH(rho=0, gamma=0) -32.5110651 9.269880 3.5071723 350 -0.37657321
#> 283 WLR FH(rho=0, gamma=0) -24.2079712 8.623443 2.8072279 301 -0.32503602
#> 284 WLR FH(rho=0, gamma=0) -32.5110651 9.269880 3.5071723 350 -0.37657321
#> 285 WLR FH(rho=0, gamma=0) -32.5110651 9.269880 3.5071723 350 -0.37657321
#> 286 WLR FH(rho=0, gamma=0) -20.7983230 8.859960 2.3474510 318 -0.26438918
#> 287 WLR FH(rho=0, gamma=0) -20.2144271 9.279368 2.1784271 350 -0.23403886
#> 288 WLR FH(rho=0, gamma=0) -21.2752964 8.876511 2.3968083 319 -0.26946334
#> 289 WLR FH(rho=0, gamma=0) -20.2144271 9.279368 2.1784271 350 -0.23403886
#> 290 WLR FH(rho=0, gamma=0) -20.2144271 9.279368 2.1784271 350 -0.23403886
#> 291 WLR FH(rho=0, gamma=0) -28.3693150 8.596777 3.2999945 299 -0.38379989
#> 292 WLR FH(rho=0, gamma=0) -32.6716177 9.283025 3.5195013 350 -0.37774753
#> 293 WLR FH(rho=0, gamma=0) -26.5955621 8.724288 3.0484508 308 -0.34883979
#> 294 WLR FH(rho=0, gamma=0) -32.6716177 9.283025 3.5195013 350 -0.37774753
#> 295 WLR FH(rho=0, gamma=0) -32.6716177 9.283025 3.5195013 350 -0.37774753
#> 296 WLR FH(rho=0, gamma=0) -20.1023966 9.026632 2.2270096 330 -0.24670874
#> 297 WLR FH(rho=0, gamma=0) -16.1423656 9.262324 1.7427986 350 -0.18795404
#> 298 WLR FH(rho=0, gamma=0) -19.7872376 9.036012 2.1898198 331 -0.24230264
#> 299 WLR FH(rho=0, gamma=0) -16.1423656 9.262324 1.7427986 350 -0.18795404
#> 300 WLR FH(rho=0, gamma=0) -16.1423656 9.262324 1.7427986 350 -0.18795404
#> 301 WLR FH(rho=0, gamma=0) -21.2849101 8.837465 2.4084860 317 -0.27231364
#> 302 WLR FH(rho=0, gamma=0) -27.9937093 9.260923 3.0227773 350 -0.32602460
#> 303 WLR FH(rho=0, gamma=0) -19.8043341 8.698733 2.2766919 306 -0.26150814
#> 304 WLR FH(rho=0, gamma=0) -27.9937093 9.260923 3.0227773 350 -0.32602460
#> 305 WLR FH(rho=0, gamma=0) -27.9937093 9.260923 3.0227773 350 -0.32602460
#> 306 WLR FH(rho=0, gamma=0) -38.0167975 8.672271 4.3837189 309 -0.50317572
#> 307 WLR FH(rho=0, gamma=0) -38.8017148 9.209929 4.2130310 350 -0.45344774
#> 308 WLR FH(rho=0, gamma=0) -38.7382981 8.646009 4.4804833 307 -0.51619903
#> 309 WLR FH(rho=0, gamma=0) -38.8017148 9.209929 4.2130310 350 -0.45344774
#> 310 WLR FH(rho=0, gamma=0) -38.8017148 9.209929 4.2130310 350 -0.45344774
#> 311 WLR FH(rho=0, gamma=0) -31.5500449 8.728973 3.6144053 312 -0.41218555
#> 312 WLR FH(rho=0, gamma=0) -33.5707879 9.228675 3.6376608 350 -0.39173072
#> 313 WLR FH(rho=0, gamma=0) -31.2245920 8.799806 3.5483274 317 -0.40131080
#> 314 WLR FH(rho=0, gamma=0) -33.5707879 9.228675 3.6376608 350 -0.39173072
#> 315 WLR FH(rho=0, gamma=0) -33.5707879 9.228675 3.6376608 350 -0.39173072
#> 316 WLR FH(rho=0, gamma=0) -8.0914921 8.610966 0.9396730 300 -0.10920134
#> 317 WLR FH(rho=0, gamma=0) -14.6185351 9.290948 1.5734169 350 -0.16965109
#> 318 WLR FH(rho=0, gamma=0) -7.7090075 8.667948 0.8893694 304 -0.10267838
#> 319 WLR FH(rho=0, gamma=0) -14.6185351 9.290948 1.5734169 350 -0.16965109
#> 320 WLR FH(rho=0, gamma=0) -14.6185351 9.290948 1.5734169 350 -0.16965109
#> 321 WLR FH(rho=0, gamma=0) -28.3636428 8.679257 3.2679806 308 -0.37406447
#> 322 WLR FH(rho=0, gamma=0) -36.5396329 9.217415 3.9641951 350 -0.42623585
#> 323 WLR FH(rho=0, gamma=0) -29.5475160 8.706788 3.3936184 310 -0.38724685
#> 324 WLR FH(rho=0, gamma=0) -36.5396329 9.217415 3.9641951 350 -0.42623585
#> 325 WLR FH(rho=0, gamma=0) -36.5396329 9.217415 3.9641951 350 -0.42623585
#> 326 WLR FH(rho=0, gamma=0) -27.3645461 8.532053 3.2072641 296 -0.37547819
#> 327 WLR FH(rho=0, gamma=0) -33.6722093 9.250005 3.6402369 350 -0.39185302
#> 328 WLR FH(rho=0, gamma=0) -28.1095050 8.963658 3.1359414 327 -0.34878440
#> 329 WLR FH(rho=0, gamma=0) -33.6722093 9.250005 3.6402369 350 -0.39185302
#> 330 WLR FH(rho=0, gamma=0) -33.6722093 9.250005 3.6402369 350 -0.39185302
#> 331 WLR FH(rho=0, gamma=0) -28.4810664 8.550020 3.3311113 302 -0.38928141
#> 332 WLR FH(rho=0, gamma=0) -34.1021208 9.198815 3.7072297 350 -0.40185339
#> 333 WLR FH(rho=0, gamma=0) -28.4518821 8.550155 3.3276454 302 -0.38888359
#> 334 WLR FH(rho=0, gamma=0) -34.1021208 9.198815 3.7072297 350 -0.40185339
#> 335 WLR FH(rho=0, gamma=0) -34.1021208 9.198815 3.7072297 350 -0.40185339
#> 336 WLR FH(rho=0, gamma=0) -19.0384150 8.773094 2.1700913 310 -0.24723023
#> 337 WLR FH(rho=0, gamma=0) -20.7336976 9.316450 2.2254934 350 -0.23843891
#> 338 WLR FH(rho=0, gamma=0) -18.1654084 8.801324 2.0639404 312 -0.23431749
#> 339 WLR FH(rho=0, gamma=0) -20.7336976 9.316450 2.2254934 350 -0.23843891
#> 340 WLR FH(rho=0, gamma=0) -20.7336976 9.316450 2.2254934 350 -0.23843891
#> 341 WLR FH(rho=0, gamma=0) -36.2145719 8.641944 4.1905587 306 -0.48133479
#> 342 WLR FH(rho=0, gamma=0) -44.8561430 9.221222 4.8644469 350 -0.52256152
#> 343 WLR FH(rho=0, gamma=0) -38.8078382 8.796943 4.4115140 318 -0.49735704
#> 344 WLR FH(rho=0, gamma=0) -44.8561430 9.221222 4.8644469 350 -0.52256152
#> 345 WLR FH(rho=0, gamma=0) -44.8561430 9.221222 4.8644469 350 -0.52256152
#> 346 WLR FH(rho=0, gamma=0) -12.2370463 9.013367 1.3576553 327 -0.15065680
#> 347 WLR FH(rho=0, gamma=0) -14.9133697 9.321771 1.5998429 350 -0.17163540
#> 348 WLR FH(rho=0, gamma=0) -12.9371145 9.025338 1.4334217 328 -0.15885893
#> 349 WLR FH(rho=0, gamma=0) -14.9133697 9.321771 1.5998429 350 -0.17163540
#> 350 WLR FH(rho=0, gamma=0) -14.9133697 9.321771 1.5998429 350 -0.17163540
#> 351 WLR FH(rho=0, gamma=0) -23.7809786 8.649382 2.7494426 303 -0.31793423
#> 352 WLR FH(rho=0, gamma=0) -28.6753790 9.259018 3.0970216 350 -0.33394744
#> 353 WLR FH(rho=0, gamma=0) -24.3861385 8.464995 2.8808213 290 -0.34087875
#> 354 WLR FH(rho=0, gamma=0) -28.6753790 9.259018 3.0970216 350 -0.33394744
#> 355 WLR FH(rho=0, gamma=0) -28.6753790 9.259018 3.0970216 350 -0.33394744
#> 356 WLR FH(rho=0, gamma=0) -29.3242147 8.794466 3.3343942 311 -0.38056054
#> 357 WLR FH(rho=0, gamma=0) -31.9000598 9.298081 3.4308219 350 -0.36874470
#> 358 WLR FH(rho=0, gamma=0) -28.3440620 8.899254 3.1849931 319 -0.35862222
#> 359 WLR FH(rho=0, gamma=0) -31.9000598 9.298081 3.4308219 350 -0.36874470
#> 360 WLR FH(rho=0, gamma=0) -31.9000598 9.298081 3.4308219 350 -0.36874470
#> 361 WLR FH(rho=0, gamma=0) -35.3461314 9.005879 3.9247843 331 -0.43374106
#> 362 WLR FH(rho=0, gamma=0) -34.9733191 9.251655 3.7802230 350 -0.40585114
#> 363 WLR FH(rho=0, gamma=0) -31.6251472 8.791565 3.5972149 315 -0.40753805
#> 364 WLR FH(rho=0, gamma=0) -34.9733191 9.251655 3.7802230 350 -0.40585114
#> 365 WLR FH(rho=0, gamma=0) -34.9733191 9.251655 3.7802230 350 -0.40585114
#> 366 WLR FH(rho=0, gamma=0) -15.4347160 8.500415 1.8157602 291 -0.21384627
#> 367 WLR FH(rho=0, gamma=0) -19.6433871 9.316694 2.1084074 350 -0.22632947
#> 368 WLR FH(rho=0, gamma=0) -13.4272582 8.696195 1.5440382 305 -0.17754614
#> 369 WLR FH(rho=0, gamma=0) -19.6433871 9.316694 2.1084074 350 -0.22632947
#> 370 WLR FH(rho=0, gamma=0) -19.6433871 9.316694 2.1084074 350 -0.22632947
#> 371 WLR FH(rho=0, gamma=0) -18.7436663 8.623776 2.1734871 301 -0.25100528
#> 372 WLR FH(rho=0, gamma=0) -26.9020076 9.292129 2.8951392 350 -0.31023621
#> 373 WLR FH(rho=0, gamma=0) -19.2071688 8.610025 2.2307913 300 -0.25804102
#> 374 WLR FH(rho=0, gamma=0) -26.9020076 9.292129 2.8951392 350 -0.31023621
#> 375 WLR FH(rho=0, gamma=0) -26.9020076 9.292129 2.8951392 350 -0.31023621
#> 376 WLR FH(rho=0, gamma=0) -35.3111091 8.905870 3.9649255 325 -0.44253408
#> 377 WLR FH(rho=0, gamma=0) -36.1314376 9.229447 3.9148000 350 -0.42038790
#> 378 WLR FH(rho=0, gamma=0) -36.4462738 8.837660 4.1239734 320 -0.46411619
#> 379 WLR FH(rho=0, gamma=0) -36.1314376 9.229447 3.9148000 350 -0.42038790
#> 380 WLR FH(rho=0, gamma=0) -36.1314376 9.229447 3.9148000 350 -0.42038790
#> 381 WLR FH(rho=0, gamma=0) -16.6404970 8.273907 2.0112018 277 -0.24321935
#> 382 WLR FH(rho=0, gamma=0) -29.9684548 9.273630 3.2315777 350 -0.34827060
#> 383 WLR FH(rho=0, gamma=0) -20.0382046 8.487676 2.3608587 292 -0.27841305
#> 384 WLR FH(rho=0, gamma=0) -29.9684548 9.273630 3.2315777 350 -0.34827060
#> 385 WLR FH(rho=0, gamma=0) -29.9684548 9.273630 3.2315777 350 -0.34827060
#> 386 WLR FH(rho=0, gamma=0) -10.1918884 8.802223 1.1578767 311 -0.13163622
#> 387 WLR FH(rho=0, gamma=0) -16.9915220 9.333177 1.8205507 350 -0.19524901
#> 388 WLR FH(rho=0, gamma=0) -9.0809545 8.744116 1.0385217 307 -0.11883241
#> 389 WLR FH(rho=0, gamma=0) -16.9915220 9.333177 1.8205507 350 -0.19524901
#> 390 WLR FH(rho=0, gamma=0) -16.9915220 9.333177 1.8205507 350 -0.19524901
#> 391 WLR FH(rho=0, gamma=0) -32.7071203 8.767652 3.7304311 316 -0.42336530
#> 392 WLR FH(rho=0, gamma=0) -39.6991814 9.230717 4.3007688 350 -0.46295093
#> 393 WLR FH(rho=0, gamma=0) -32.2419684 8.584524 3.7558249 302 -0.43569144
#> 394 WLR FH(rho=0, gamma=0) -39.6991814 9.230717 4.3007688 350 -0.46295093
#> 395 WLR FH(rho=0, gamma=0) -39.6991814 9.230717 4.3007688 350 -0.46295093
#> 396 WLR FH(rho=0, gamma=0) -30.2340268 8.812418 3.4308435 315 -0.38811446
#> 397 WLR FH(rho=0, gamma=0) -37.1491710 9.250243 4.0160210 350 -0.43190231
#> 398 WLR FH(rho=0, gamma=0) -30.2214143 8.812557 3.4293581 315 -0.38794459
#> 399 WLR FH(rho=0, gamma=0) -37.1491710 9.250243 4.0160210 350 -0.43190231
#> 400 WLR FH(rho=0, gamma=0) -37.1491710 9.250243 4.0160210 350 -0.43190231
#> 401 WLR FH(rho=0, gamma=0) -26.1910959 8.388806 3.1221481 284 -0.37198839
#> 402 WLR FH(rho=0, gamma=0) -37.3801749 9.286799 4.0250873 350 -0.43194685
#> 403 WLR FH(rho=0, gamma=0) -26.2377712 8.520171 3.0794889 293 -0.36102236
#> 404 WLR FH(rho=0, gamma=0) -37.3801749 9.286799 4.0250873 350 -0.43194685
#> 405 WLR FH(rho=0, gamma=0) -37.3801749 9.286799 4.0250873 350 -0.43194685
#> 406 WLR FH(rho=0, gamma=0) -15.0210964 8.622376 1.7421064 300 -0.20192420
#> 407 WLR FH(rho=0, gamma=0) -21.5072036 9.290768 2.3149006 350 -0.24881469
#> 408 WLR FH(rho=0, gamma=0) -16.2064261 8.679142 1.8672843 304 -0.21504560
#> 409 WLR FH(rho=0, gamma=0) -21.5072036 9.290768 2.3149006 350 -0.24881469
#> 410 WLR FH(rho=0, gamma=0) -21.5072036 9.290768 2.3149006 350 -0.24881469
#> 411 WLR FH(rho=0, gamma=0) -21.6514790 9.036693 2.3959515 328 -0.26526608
#> 412 WLR FH(rho=0, gamma=0) -20.4129303 9.314820 2.1914466 350 -0.23510330
#> 413 WLR FH(rho=0, gamma=0) -21.7186851 8.842200 2.4562536 314 -0.27818709
#> 414 WLR FH(rho=0, gamma=0) -20.4129303 9.314820 2.1914466 350 -0.23510330
#> 415 WLR FH(rho=0, gamma=0) -20.4129303 9.314820 2.1914466 350 -0.23510330
#> 416 WLR FH(rho=0, gamma=0) -33.7249398 8.735209 3.8608052 311 -0.44157461
#> 417 WLR FH(rho=0, gamma=0) -36.0879548 9.252835 3.9002052 350 -0.41967250
#> 418 WLR FH(rho=0, gamma=0) -33.6476039 8.637485 3.8955324 304 -0.45094498
#> 419 WLR FH(rho=0, gamma=0) -36.0879548 9.252835 3.9002052 350 -0.41967250
#> 420 WLR FH(rho=0, gamma=0) -36.0879548 9.252835 3.9002052 350 -0.41967250
#> 421 WLR FH(rho=0, gamma=0) -28.0598232 8.878232 3.1605194 319 -0.35651471
#> 422 WLR FH(rho=0, gamma=0) -32.8377892 9.272687 3.5413457 350 -0.38149191
#> 423 WLR FH(rho=0, gamma=0) -27.7304977 8.891535 3.1187527 320 -0.35115956
#> 424 WLR FH(rho=0, gamma=0) -32.8377892 9.272687 3.5413457 350 -0.38149191
#> 425 WLR FH(rho=0, gamma=0) -32.8377892 9.272687 3.5413457 350 -0.38149191
#> 426 WLR FH(rho=0, gamma=0) -16.8796636 8.652162 1.9509186 302 -0.22646932
#> 427 WLR FH(rho=0, gamma=0) -21.7520137 9.290600 2.3412927 350 -0.25254519
#> 428 WLR FH(rho=0, gamma=0) -17.8883948 8.723562 2.0505838 307 -0.23608854
#> 429 WLR FH(rho=0, gamma=0) -21.7520137 9.290600 2.3412927 350 -0.25254519
#> 430 WLR FH(rho=0, gamma=0) -21.7520137 9.290600 2.3412927 350 -0.25254519
#> 431 WLR FH(rho=0, gamma=0) -30.7764712 8.720117 3.5293643 310 -0.40415776
#> 432 WLR FH(rho=0, gamma=0) -34.5457375 9.239966 3.7387300 350 -0.40258926
#> 433 WLR FH(rho=0, gamma=0) -29.5197099 8.641026 3.4162276 305 -0.39467379
#> 434 WLR FH(rho=0, gamma=0) -34.5457375 9.239966 3.7387300 350 -0.40258926
#> 435 WLR FH(rho=0, gamma=0) -34.5457375 9.239966 3.7387300 350 -0.40258926
#> 436 WLR FH(rho=0, gamma=0) -15.3083984 8.615245 1.7768964 302 -0.20610909
#> 437 WLR FH(rho=0, gamma=0) -18.6149864 9.291421 2.0034596 350 -0.21523088
#> 438 WLR FH(rho=0, gamma=0) -14.1780526 8.486168 1.6707249 292 -0.19677809
#> 439 WLR FH(rho=0, gamma=0) -18.6149864 9.291421 2.0034596 350 -0.21523088
#> 440 WLR FH(rho=0, gamma=0) -18.6149864 9.291421 2.0034596 350 -0.21523088
#> 441 WLR FH(rho=0, gamma=0) -37.6588438 8.588546 4.3847750 306 -0.50715388
#> 442 WLR FH(rho=0, gamma=0) -48.2316074 9.136277 5.2791312 350 -0.57198040
#> 443 WLR FH(rho=0, gamma=0) -37.0505446 8.678654 4.2691578 312 -0.48823835
#> 444 WLR FH(rho=0, gamma=0) -48.2316074 9.136277 5.2791312 350 -0.57198040
#> 445 WLR FH(rho=0, gamma=0) -48.2316074 9.136277 5.2791312 350 -0.57198040
#> 446 WLR FH(rho=0, gamma=0) -31.3178955 8.718445 3.5921423 310 -0.41064734
#> 447 WLR FH(rho=0, gamma=0) -31.3385454 9.234562 3.3936146 350 -0.36525270
#> 448 WLR FH(rho=0, gamma=0) -29.4467733 8.843447 3.3297847 319 -0.37487251
#> 449 WLR FH(rho=0, gamma=0) -31.3385454 9.234562 3.3936146 350 -0.36525270
#> 450 WLR FH(rho=0, gamma=0) -31.3385454 9.234562 3.3936146 350 -0.36525270
#> 451 WLR FH(rho=0, gamma=0) -20.7261096 8.994767 2.3042408 332 -0.25640419
#> 452 WLR FH(rho=0, gamma=0) -21.1788273 9.218017 2.2975470 350 -0.24929101
#> 453 WLR FH(rho=0, gamma=0) -20.5334548 8.944242 2.2957176 328 -0.25690650
#> 454 WLR FH(rho=0, gamma=0) -21.1788273 9.218017 2.2975470 350 -0.24929101
#> 455 WLR FH(rho=0, gamma=0) -21.1788273 9.218017 2.2975470 350 -0.24929101
#> 456 WLR FH(rho=0, gamma=0) -21.1948804 8.677903 2.4423964 304 -0.28093426
#> 457 WLR FH(rho=0, gamma=0) -28.7057042 9.293928 3.0886516 350 -0.33108930
#> 458 WLR FH(rho=0, gamma=0) -19.9158746 8.622416 2.3097788 300 -0.26736641
#> 459 WLR FH(rho=0, gamma=0) -28.7057042 9.293928 3.0886516 350 -0.33108930
#> 460 WLR FH(rho=0, gamma=0) -28.7057042 9.293928 3.0886516 350 -0.33108930
#> 461 WLR FH(rho=0, gamma=0) -30.8026800 8.675805 3.5504119 308 -0.40643765
#> 462 WLR FH(rho=0, gamma=0) -33.8214777 9.220600 3.6680344 350 -0.39380522
#> 463 WLR FH(rho=0, gamma=0) -29.7109833 8.413522 3.5313371 290 -0.41707013
#> 464 WLR FH(rho=0, gamma=0) -33.8214777 9.220600 3.6680344 350 -0.39380522
#> 465 WLR FH(rho=0, gamma=0) -33.8214777 9.220600 3.6680344 350 -0.39380522
#> 466 WLR FH(rho=0, gamma=0) -14.8926212 8.956359 1.6627986 325 -0.18549373
#> 467 WLR FH(rho=0, gamma=0) -16.7094922 9.305772 1.7956052 350 -0.19278341
#> 468 WLR FH(rho=0, gamma=0) -15.3230804 8.914635 1.7188679 322 -0.19266225
#> 469 WLR FH(rho=0, gamma=0) -16.7094922 9.305772 1.7956052 350 -0.19278341
#> 470 WLR FH(rho=0, gamma=0) -16.7094922 9.305772 1.7956052 350 -0.19278341
#> 471 WLR FH(rho=0, gamma=0) -34.7381647 8.608903 4.0351441 305 -0.46975762
#> 472 WLR FH(rho=0, gamma=0) -35.3079683 9.219775 3.8295910 350 -0.41391937
#> 473 WLR FH(rho=0, gamma=0) -33.0776295 8.493712 3.8943667 296 -0.45961010
#> 474 WLR FH(rho=0, gamma=0) -35.3079683 9.219775 3.8295910 350 -0.41391937
#> 475 WLR FH(rho=0, gamma=0) -35.3079683 9.219775 3.8295910 350 -0.41391937
#> 476 WLR FH(rho=0, gamma=0) -29.8788441 8.777301 3.4041040 315 -0.38712513
#> 477 WLR FH(rho=0, gamma=0) -38.5222224 9.228203 4.1744012 350 -0.45093611
#> 478 WLR FH(rho=0, gamma=0) -30.3654327 8.792151 3.4536978 316 -0.39217647
#> 479 WLR FH(rho=0, gamma=0) -38.5222224 9.228203 4.1744012 350 -0.45093611
#> 480 WLR FH(rho=0, gamma=0) -38.5222224 9.228203 4.1744012 350 -0.45093611
#> 481 WLR FH(rho=0, gamma=0) -16.2464302 8.928742 1.8195653 322 -0.20359274
#> 482 WLR FH(rho=0, gamma=0) -13.3050575 9.295157 1.4313967 350 -0.15377723
#> 483 WLR FH(rho=0, gamma=0) -16.7710964 8.942694 1.8753965 323 -0.20952779
#> 484 WLR FH(rho=0, gamma=0) -13.3050575 9.295157 1.4313967 350 -0.15377723
#> 485 WLR FH(rho=0, gamma=0) -13.3050575 9.295157 1.4313967 350 -0.15377723
#> 486 WLR FH(rho=0, gamma=0) -34.0449216 9.116042 3.7346165 338 -0.40799397
#> 487 WLR FH(rho=0, gamma=0) -34.7017497 9.261516 3.7468756 350 -0.40241159
#> 488 WLR FH(rho=0, gamma=0) -30.4212672 8.889081 3.4223187 321 -0.38388611
#> 489 WLR FH(rho=0, gamma=0) -34.7017497 9.261516 3.7468756 350 -0.40241159
#> 490 WLR FH(rho=0, gamma=0) -34.7017497 9.261516 3.7468756 350 -0.40241159
#> 491 WLR FH(rho=0, gamma=0) -17.8836796 8.418139 2.1244221 286 -0.25249284
#> 492 WLR FH(rho=0, gamma=0) -25.8594765 9.302088 2.7799647 350 -0.29835075
#> 493 WLR FH(rho=0, gamma=0) -18.9827582 8.767904 2.1650280 311 -0.24663524
#> 494 WLR FH(rho=0, gamma=0) -25.8594765 9.302088 2.7799647 350 -0.29835075
#> 495 WLR FH(rho=0, gamma=0) -25.8594765 9.302088 2.7799647 350 -0.29835075
#> 496 WLR FH(rho=0, gamma=0) -18.8356278 8.645086 2.1787671 302 -0.25193622
#> 497 WLR FH(rho=0, gamma=0) -23.5941053 9.281569 2.5420385 350 -0.27316591
#> 498 WLR FH(rho=0, gamma=0) -20.3968493 8.686215 2.3481862 305 -0.27033093
#> 499 WLR FH(rho=0, gamma=0) -23.5941053 9.281569 2.5420385 350 -0.27316591
#> 500 WLR FH(rho=0, gamma=0) -23.5941053 9.281569 2.5420385 350 -0.27316591
#> cut duration sim
#> 1 Planned duration 30.00000 1
#> 2 Targeted events 34.56252 1
#> 3 Minimum follow-up 30.26592 1
#> 4 Max(planned duration, event cut) 34.56252 1
#> 5 Max(min follow-up, event cut) 34.56252 1
#> 6 Planned duration 30.00000 2
#> 7 Targeted events 31.32993 2
#> 8 Minimum follow-up 30.19554 2
#> 9 Max(planned duration, event cut) 31.32993 2
#> 10 Max(min follow-up, event cut) 31.32993 2
#> 11 Planned duration 30.00000 3
#> 12 Targeted events 36.44080 3
#> 13 Minimum follow-up 31.44128 3
#> 14 Max(planned duration, event cut) 36.44080 3
#> 15 Max(min follow-up, event cut) 36.44080 3
#> 16 Planned duration 30.00000 4
#> 17 Targeted events 34.65063 4
#> 18 Minimum follow-up 29.90029 4
#> 19 Max(planned duration, event cut) 34.65063 4
#> 20 Max(min follow-up, event cut) 34.65063 4
#> 21 Planned duration 30.00000 5
#> 22 Targeted events 33.46261 5
#> 23 Minimum follow-up 28.83239 5
#> 24 Max(planned duration, event cut) 33.46261 5
#> 25 Max(min follow-up, event cut) 33.46261 5
#> 26 Planned duration 30.00000 6
#> 27 Targeted events 36.65492 6
#> 28 Minimum follow-up 30.98457 6
#> 29 Max(planned duration, event cut) 36.65492 6
#> 30 Max(min follow-up, event cut) 36.65492 6
#> 31 Planned duration 30.00000 7
#> 32 Targeted events 31.07340 7
#> 33 Minimum follow-up 28.80649 7
#> 34 Max(planned duration, event cut) 31.07340 7
#> 35 Max(min follow-up, event cut) 31.07340 7
#> 36 Planned duration 30.00000 8
#> 37 Targeted events 33.95026 8
#> 38 Minimum follow-up 31.19859 8
#> 39 Max(planned duration, event cut) 33.95026 8
#> 40 Max(min follow-up, event cut) 33.95026 8
#> 41 Planned duration 30.00000 9
#> 42 Targeted events 33.20459 9
#> 43 Minimum follow-up 29.69966 9
#> 44 Max(planned duration, event cut) 33.20459 9
#> 45 Max(min follow-up, event cut) 33.20459 9
#> 46 Planned duration 30.00000 10
#> 47 Targeted events 34.49827 10
#> 48 Minimum follow-up 28.50262 10
#> 49 Max(planned duration, event cut) 34.49827 10
#> 50 Max(min follow-up, event cut) 34.49827 10
#> 51 Planned duration 30.00000 11
#> 52 Targeted events 34.65074 11
#> 53 Minimum follow-up 29.31876 11
#> 54 Max(planned duration, event cut) 34.65074 11
#> 55 Max(min follow-up, event cut) 34.65074 11
#> 56 Planned duration 30.00000 12
#> 57 Targeted events 32.44983 12
#> 58 Minimum follow-up 29.65292 12
#> 59 Max(planned duration, event cut) 32.44983 12
#> 60 Max(min follow-up, event cut) 32.44983 12
#> 61 Planned duration 30.00000 13
#> 62 Targeted events 31.55883 13
#> 63 Minimum follow-up 28.91997 13
#> 64 Max(planned duration, event cut) 31.55883 13
#> 65 Max(min follow-up, event cut) 31.55883 13
#> 66 Planned duration 30.00000 14
#> 67 Targeted events 35.79983 14
#> 68 Minimum follow-up 33.72392 14
#> 69 Max(planned duration, event cut) 35.79983 14
#> 70 Max(min follow-up, event cut) 35.79983 14
#> 71 Planned duration 30.00000 15
#> 72 Targeted events 35.03286 15
#> 73 Minimum follow-up 30.38550 15
#> 74 Max(planned duration, event cut) 35.03286 15
#> 75 Max(min follow-up, event cut) 35.03286 15
#> 76 Planned duration 30.00000 16
#> 77 Targeted events 34.98842 16
#> 78 Minimum follow-up 29.75020 16
#> 79 Max(planned duration, event cut) 34.98842 16
#> 80 Max(min follow-up, event cut) 34.98842 16
#> 81 Planned duration 30.00000 17
#> 82 Targeted events 34.99259 17
#> 83 Minimum follow-up 30.60927 17
#> 84 Max(planned duration, event cut) 34.99259 17
#> 85 Max(min follow-up, event cut) 34.99259 17
#> 86 Planned duration 30.00000 18
#> 87 Targeted events 33.31031 18
#> 88 Minimum follow-up 28.31274 18
#> 89 Max(planned duration, event cut) 33.31031 18
#> 90 Max(min follow-up, event cut) 33.31031 18
#> 91 Planned duration 30.00000 19
#> 92 Targeted events 35.08991 19
#> 93 Minimum follow-up 28.98224 19
#> 94 Max(planned duration, event cut) 35.08991 19
#> 95 Max(min follow-up, event cut) 35.08991 19
#> 96 Planned duration 30.00000 20
#> 97 Targeted events 36.42758 20
#> 98 Minimum follow-up 30.30389 20
#> 99 Max(planned duration, event cut) 36.42758 20
#> 100 Max(min follow-up, event cut) 36.42758 20
#> 101 Planned duration 30.00000 21
#> 102 Targeted events 31.24966 21
#> 103 Minimum follow-up 30.17003 21
#> 104 Max(planned duration, event cut) 31.24966 21
#> 105 Max(min follow-up, event cut) 31.24966 21
#> 106 Planned duration 30.00000 22
#> 107 Targeted events 35.50895 22
#> 108 Minimum follow-up 28.10047 22
#> 109 Max(planned duration, event cut) 35.50895 22
#> 110 Max(min follow-up, event cut) 35.50895 22
#> 111 Planned duration 30.00000 23
#> 112 Targeted events 32.53926 23
#> 113 Minimum follow-up 29.50244 23
#> 114 Max(planned duration, event cut) 32.53926 23
#> 115 Max(min follow-up, event cut) 32.53926 23
#> 116 Planned duration 30.00000 24
#> 117 Targeted events 34.93207 24
#> 118 Minimum follow-up 29.68265 24
#> 119 Max(planned duration, event cut) 34.93207 24
#> 120 Max(min follow-up, event cut) 34.93207 24
#> 121 Planned duration 30.00000 25
#> 122 Targeted events 34.95328 25
#> 123 Minimum follow-up 31.35324 25
#> 124 Max(planned duration, event cut) 34.95328 25
#> 125 Max(min follow-up, event cut) 34.95328 25
#> 126 Planned duration 30.00000 26
#> 127 Targeted events 32.22708 26
#> 128 Minimum follow-up 29.50572 26
#> 129 Max(planned duration, event cut) 32.22708 26
#> 130 Max(min follow-up, event cut) 32.22708 26
#> 131 Planned duration 30.00000 27
#> 132 Targeted events 34.08638 27
#> 133 Minimum follow-up 30.70187 27
#> 134 Max(planned duration, event cut) 34.08638 27
#> 135 Max(min follow-up, event cut) 34.08638 27
#> 136 Planned duration 30.00000 28
#> 137 Targeted events 33.57268 28
#> 138 Minimum follow-up 30.35670 28
#> 139 Max(planned duration, event cut) 33.57268 28
#> 140 Max(min follow-up, event cut) 33.57268 28
#> 141 Planned duration 30.00000 29
#> 142 Targeted events 31.76390 29
#> 143 Minimum follow-up 28.44688 29
#> 144 Max(planned duration, event cut) 31.76390 29
#> 145 Max(min follow-up, event cut) 31.76390 29
#> 146 Planned duration 30.00000 30
#> 147 Targeted events 35.52284 30
#> 148 Minimum follow-up 31.28813 30
#> 149 Max(planned duration, event cut) 35.52284 30
#> 150 Max(min follow-up, event cut) 35.52284 30
#> 151 Planned duration 30.00000 31
#> 152 Targeted events 36.75499 31
#> 153 Minimum follow-up 29.59861 31
#> 154 Max(planned duration, event cut) 36.75499 31
#> 155 Max(min follow-up, event cut) 36.75499 31
#> 156 Planned duration 30.00000 32
#> 157 Targeted events 35.32287 32
#> 158 Minimum follow-up 30.87719 32
#> 159 Max(planned duration, event cut) 35.32287 32
#> 160 Max(min follow-up, event cut) 35.32287 32
#> 161 Planned duration 30.00000 33
#> 162 Targeted events 34.21867 33
#> 163 Minimum follow-up 28.99271 33
#> 164 Max(planned duration, event cut) 34.21867 33
#> 165 Max(min follow-up, event cut) 34.21867 33
#> 166 Planned duration 30.00000 34
#> 167 Targeted events 32.81083 34
#> 168 Minimum follow-up 29.61577 34
#> 169 Max(planned duration, event cut) 32.81083 34
#> 170 Max(min follow-up, event cut) 32.81083 34
#> 171 Planned duration 30.00000 35
#> 172 Targeted events 35.08037 35
#> 173 Minimum follow-up 29.74254 35
#> 174 Max(planned duration, event cut) 35.08037 35
#> 175 Max(min follow-up, event cut) 35.08037 35
#> 176 Planned duration 30.00000 36
#> 177 Targeted events 31.99763 36
#> 178 Minimum follow-up 27.73686 36
#> 179 Max(planned duration, event cut) 31.99763 36
#> 180 Max(min follow-up, event cut) 31.99763 36
#> 181 Planned duration 30.00000 37
#> 182 Targeted events 35.13270 37
#> 183 Minimum follow-up 28.39063 37
#> 184 Max(planned duration, event cut) 35.13270 37
#> 185 Max(min follow-up, event cut) 35.13270 37
#> 186 Planned duration 30.00000 38
#> 187 Targeted events 33.15620 38
#> 188 Minimum follow-up 28.16147 38
#> 189 Max(planned duration, event cut) 33.15620 38
#> 190 Max(min follow-up, event cut) 33.15620 38
#> 191 Planned duration 30.00000 39
#> 192 Targeted events 33.15477 39
#> 193 Minimum follow-up 29.98781 39
#> 194 Max(planned duration, event cut) 33.15477 39
#> 195 Max(min follow-up, event cut) 33.15477 39
#> 196 Planned duration 30.00000 40
#> 197 Targeted events 35.32938 40
#> 198 Minimum follow-up 30.93153 40
#> 199 Max(planned duration, event cut) 35.32938 40
#> 200 Max(min follow-up, event cut) 35.32938 40
#> 201 Planned duration 30.00000 41
#> 202 Targeted events 34.75173 41
#> 203 Minimum follow-up 31.36614 41
#> 204 Max(planned duration, event cut) 34.75173 41
#> 205 Max(min follow-up, event cut) 34.75173 41
#> 206 Planned duration 30.00000 42
#> 207 Targeted events 33.78014 42
#> 208 Minimum follow-up 27.71455 42
#> 209 Max(planned duration, event cut) 33.78014 42
#> 210 Max(min follow-up, event cut) 33.78014 42
#> 211 Planned duration 30.00000 43
#> 212 Targeted events 33.92332 43
#> 213 Minimum follow-up 29.67460 43
#> 214 Max(planned duration, event cut) 33.92332 43
#> 215 Max(min follow-up, event cut) 33.92332 43
#> 216 Planned duration 30.00000 44
#> 217 Targeted events 35.00782 44
#> 218 Minimum follow-up 31.53494 44
#> 219 Max(planned duration, event cut) 35.00782 44
#> 220 Max(min follow-up, event cut) 35.00782 44
#> 221 Planned duration 30.00000 45
#> 222 Targeted events 32.69217 45
#> 223 Minimum follow-up 31.19296 45
#> 224 Max(planned duration, event cut) 32.69217 45
#> 225 Max(min follow-up, event cut) 32.69217 45
#> 226 Planned duration 30.00000 46
#> 227 Targeted events 33.96500 46
#> 228 Minimum follow-up 30.39167 46
#> 229 Max(planned duration, event cut) 33.96500 46
#> 230 Max(min follow-up, event cut) 33.96500 46
#> 231 Planned duration 30.00000 47
#> 232 Targeted events 35.09326 47
#> 233 Minimum follow-up 30.13249 47
#> 234 Max(planned duration, event cut) 35.09326 47
#> 235 Max(min follow-up, event cut) 35.09326 47
#> 236 Planned duration 30.00000 48
#> 237 Targeted events 33.46691 48
#> 238 Minimum follow-up 29.99249 48
#> 239 Max(planned duration, event cut) 33.46691 48
#> 240 Max(min follow-up, event cut) 33.46691 48
#> 241 Planned duration 30.00000 49
#> 242 Targeted events 33.11491 49
#> 243 Minimum follow-up 29.11094 49
#> 244 Max(planned duration, event cut) 33.11491 49
#> 245 Max(min follow-up, event cut) 33.11491 49
#> 246 Planned duration 30.00000 50
#> 247 Targeted events 34.73370 50
#> 248 Minimum follow-up 31.10906 50
#> 249 Max(planned duration, event cut) 34.73370 50
#> 250 Max(min follow-up, event cut) 34.73370 50
#> 251 Planned duration 30.00000 51
#> 252 Targeted events 34.81528 51
#> 253 Minimum follow-up 30.57508 51
#> 254 Max(planned duration, event cut) 34.81528 51
#> 255 Max(min follow-up, event cut) 34.81528 51
#> 256 Planned duration 30.00000 52
#> 257 Targeted events 34.62794 52
#> 258 Minimum follow-up 31.18999 52
#> 259 Max(planned duration, event cut) 34.62794 52
#> 260 Max(min follow-up, event cut) 34.62794 52
#> 261 Planned duration 30.00000 53
#> 262 Targeted events 34.06656 53
#> 263 Minimum follow-up 31.30138 53
#> 264 Max(planned duration, event cut) 34.06656 53
#> 265 Max(min follow-up, event cut) 34.06656 53
#> 266 Planned duration 30.00000 54
#> 267 Targeted events 35.10337 54
#> 268 Minimum follow-up 31.32082 54
#> 269 Max(planned duration, event cut) 35.10337 54
#> 270 Max(min follow-up, event cut) 35.10337 54
#> 271 Planned duration 30.00000 55
#> 272 Targeted events 33.08402 55
#> 273 Minimum follow-up 30.35031 55
#> 274 Max(planned duration, event cut) 33.08402 55
#> 275 Max(min follow-up, event cut) 33.08402 55
#> 276 Planned duration 30.00000 56
#> 277 Targeted events 32.14236 56
#> 278 Minimum follow-up 29.27245 56
#> 279 Max(planned duration, event cut) 32.14236 56
#> 280 Max(min follow-up, event cut) 32.14236 56
#> 281 Planned duration 30.00000 57
#> 282 Targeted events 34.93451 57
#> 283 Minimum follow-up 30.10195 57
#> 284 Max(planned duration, event cut) 34.93451 57
#> 285 Max(min follow-up, event cut) 34.93451 57
#> 286 Planned duration 30.00000 58
#> 287 Targeted events 33.38745 58
#> 288 Minimum follow-up 30.22551 58
#> 289 Max(planned duration, event cut) 33.38745 58
#> 290 Max(min follow-up, event cut) 33.38745 58
#> 291 Planned duration 30.00000 59
#> 292 Targeted events 34.95228 59
#> 293 Minimum follow-up 30.65333 59
#> 294 Max(planned duration, event cut) 34.95228 59
#> 295 Max(min follow-up, event cut) 34.95228 59
#> 296 Planned duration 30.00000 60
#> 297 Targeted events 32.87052 60
#> 298 Minimum follow-up 30.32562 60
#> 299 Max(planned duration, event cut) 32.87052 60
#> 300 Max(min follow-up, event cut) 32.87052 60
#> 301 Planned duration 30.00000 61
#> 302 Targeted events 34.24457 61
#> 303 Minimum follow-up 29.30889 61
#> 304 Max(planned duration, event cut) 34.24457 61
#> 305 Max(min follow-up, event cut) 34.24457 61
#> 306 Planned duration 30.00000 62
#> 307 Targeted events 35.22550 62
#> 308 Minimum follow-up 29.93786 62
#> 309 Max(planned duration, event cut) 35.22550 62
#> 310 Max(min follow-up, event cut) 35.22550 62
#> 311 Planned duration 30.00000 63
#> 312 Targeted events 33.82268 63
#> 313 Minimum follow-up 30.43156 63
#> 314 Max(planned duration, event cut) 33.82268 63
#> 315 Max(min follow-up, event cut) 33.82268 63
#> 316 Planned duration 30.00000 64
#> 317 Targeted events 34.47059 64
#> 318 Minimum follow-up 30.41514 64
#> 319 Max(planned duration, event cut) 34.47059 64
#> 320 Max(min follow-up, event cut) 34.47059 64
#> 321 Planned duration 30.00000 65
#> 322 Targeted events 35.20960 65
#> 323 Minimum follow-up 30.13714 65
#> 324 Max(planned duration, event cut) 35.20960 65
#> 325 Max(min follow-up, event cut) 35.20960 65
#> 326 Planned duration 30.00000 66
#> 327 Targeted events 35.92377 66
#> 328 Minimum follow-up 32.40457 66
#> 329 Max(planned duration, event cut) 35.92377 66
#> 330 Max(min follow-up, event cut) 35.92377 66
#> 331 Planned duration 30.00000 67
#> 332 Targeted events 35.65085 67
#> 333 Minimum follow-up 30.06775 67
#> 334 Max(planned duration, event cut) 35.65085 67
#> 335 Max(min follow-up, event cut) 35.65085 67
#> 336 Planned duration 30.00000 68
#> 337 Targeted events 35.06020 68
#> 338 Minimum follow-up 30.37774 68
#> 339 Max(planned duration, event cut) 35.06020 68
#> 340 Max(min follow-up, event cut) 35.06020 68
#> 341 Planned duration 30.00000 69
#> 342 Targeted events 35.08805 69
#> 343 Minimum follow-up 32.06182 69
#> 344 Max(planned duration, event cut) 35.08805 69
#> 345 Max(min follow-up, event cut) 35.08805 69
#> 346 Planned duration 30.00000 70
#> 347 Targeted events 33.54823 70
#> 348 Minimum follow-up 30.38074 70
#> 349 Max(planned duration, event cut) 33.54823 70
#> 350 Max(min follow-up, event cut) 33.54823 70
#> 351 Planned duration 30.00000 71
#> 352 Targeted events 34.47262 71
#> 353 Minimum follow-up 29.08655 71
#> 354 Max(planned duration, event cut) 34.47262 71
#> 355 Max(min follow-up, event cut) 34.47262 71
#> 356 Planned duration 30.00000 72
#> 357 Targeted events 34.40623 72
#> 358 Minimum follow-up 30.65888 72
#> 359 Max(planned duration, event cut) 34.40623 72
#> 360 Max(min follow-up, event cut) 34.40623 72
#> 361 Planned duration 30.00000 73
#> 362 Targeted events 31.57970 73
#> 363 Minimum follow-up 28.33111 73
#> 364 Max(planned duration, event cut) 31.57970 73
#> 365 Max(min follow-up, event cut) 31.57970 73
#> 366 Planned duration 30.00000 74
#> 367 Targeted events 35.86374 74
#> 368 Minimum follow-up 31.07454 74
#> 369 Max(planned duration, event cut) 35.86374 74
#> 370 Max(min follow-up, event cut) 35.86374 74
#> 371 Planned duration 30.00000 75
#> 372 Targeted events 34.79521 75
#> 373 Minimum follow-up 29.95887 75
#> 374 Max(planned duration, event cut) 34.79521 75
#> 375 Max(min follow-up, event cut) 34.79521 75
#> 376 Planned duration 30.00000 76
#> 377 Targeted events 32.80305 76
#> 378 Minimum follow-up 29.38033 76
#> 379 Max(planned duration, event cut) 32.80305 76
#> 380 Max(min follow-up, event cut) 32.80305 76
#> 381 Planned duration 30.00000 77
#> 382 Targeted events 38.39885 77
#> 383 Minimum follow-up 31.65124 77
#> 384 Max(planned duration, event cut) 38.39885 77
#> 385 Max(min follow-up, event cut) 38.39885 77
#> 386 Planned duration 30.00000 78
#> 387 Targeted events 34.87496 78
#> 388 Minimum follow-up 29.66380 78
#> 389 Max(planned duration, event cut) 34.87496 78
#> 390 Max(min follow-up, event cut) 34.87496 78
#> 391 Planned duration 30.00000 79
#> 392 Targeted events 33.95847 79
#> 393 Minimum follow-up 28.89698 79
#> 394 Max(planned duration, event cut) 33.95847 79
#> 395 Max(min follow-up, event cut) 33.95847 79
#> 396 Planned duration 30.00000 80
#> 397 Targeted events 34.91475 80
#> 398 Minimum follow-up 30.02777 80
#> 399 Max(planned duration, event cut) 34.91475 80
#> 400 Max(min follow-up, event cut) 34.91475 80
#> 401 Planned duration 30.00000 81
#> 402 Targeted events 37.03746 81
#> 403 Minimum follow-up 31.02185 81
#> 404 Max(planned duration, event cut) 37.03746 81
#> 405 Max(min follow-up, event cut) 37.03746 81
#> 406 Planned duration 30.00000 82
#> 407 Targeted events 35.18807 82
#> 408 Minimum follow-up 30.18952 82
#> 409 Max(planned duration, event cut) 35.18807 82
#> 410 Max(min follow-up, event cut) 35.18807 82
#> 411 Planned duration 30.00000 83
#> 412 Targeted events 31.91792 83
#> 413 Minimum follow-up 28.76744 83
#> 414 Max(planned duration, event cut) 31.91792 83
#> 415 Max(min follow-up, event cut) 31.91792 83
#> 416 Planned duration 30.00000 84
#> 417 Targeted events 34.25827 84
#> 418 Minimum follow-up 29.59276 84
#> 419 Max(planned duration, event cut) 34.25827 84
#> 420 Max(min follow-up, event cut) 34.25827 84
#> 421 Planned duration 30.00000 85
#> 422 Targeted events 34.13983 85
#> 423 Minimum follow-up 30.05535 85
#> 424 Max(planned duration, event cut) 34.13983 85
#> 425 Max(min follow-up, event cut) 34.13983 85
#> 426 Planned duration 30.00000 86
#> 427 Targeted events 34.67392 86
#> 428 Minimum follow-up 30.52656 86
#> 429 Max(planned duration, event cut) 34.67392 86
#> 430 Max(min follow-up, event cut) 34.67392 86
#> 431 Planned duration 30.00000 87
#> 432 Targeted events 34.10374 87
#> 433 Minimum follow-up 29.31655 87
#> 434 Max(planned duration, event cut) 34.10374 87
#> 435 Max(min follow-up, event cut) 34.10374 87
#> 436 Planned duration 30.00000 88
#> 437 Targeted events 35.22186 88
#> 438 Minimum follow-up 28.80527 88
#> 439 Max(planned duration, event cut) 35.22186 88
#> 440 Max(min follow-up, event cut) 35.22186 88
#> 441 Planned duration 30.00000 89
#> 442 Targeted events 34.40650 89
#> 443 Minimum follow-up 30.46735 89
#> 444 Max(planned duration, event cut) 34.40650 89
#> 445 Max(min follow-up, event cut) 34.40650 89
#> 446 Planned duration 30.00000 90
#> 447 Targeted events 33.09799 90
#> 448 Minimum follow-up 30.95716 90
#> 449 Max(planned duration, event cut) 33.09799 90
#> 450 Max(min follow-up, event cut) 33.09799 90
#> 451 Planned duration 30.00000 91
#> 452 Targeted events 31.97511 91
#> 453 Minimum follow-up 29.74051 91
#> 454 Max(planned duration, event cut) 31.97511 91
#> 455 Max(min follow-up, event cut) 31.97511 91
#> 456 Planned duration 30.00000 92
#> 457 Targeted events 35.49273 92
#> 458 Minimum follow-up 29.67250 92
#> 459 Max(planned duration, event cut) 35.49273 92
#> 460 Max(min follow-up, event cut) 35.49273 92
#> 461 Planned duration 30.00000 93
#> 462 Targeted events 34.59404 93
#> 463 Minimum follow-up 28.35316 93
#> 464 Max(planned duration, event cut) 34.59404 93
#> 465 Max(min follow-up, event cut) 34.59404 93
#> 466 Planned duration 30.00000 94
#> 467 Targeted events 32.20619 94
#> 468 Minimum follow-up 29.88147 94
#> 469 Max(planned duration, event cut) 32.20619 94
#> 470 Max(min follow-up, event cut) 32.20619 94
#> 471 Planned duration 30.00000 95
#> 472 Targeted events 35.40507 95
#> 473 Minimum follow-up 28.56254 95
#> 474 Max(planned duration, event cut) 35.40507 95
#> 475 Max(min follow-up, event cut) 35.40507 95
#> 476 Planned duration 30.00000 96
#> 477 Targeted events 33.61292 96
#> 478 Minimum follow-up 30.03990 96
#> 479 Max(planned duration, event cut) 33.61292 96
#> 480 Max(min follow-up, event cut) 33.61292 96
#> 481 Planned duration 30.00000 97
#> 482 Targeted events 33.18038 97
#> 483 Minimum follow-up 30.12015 97
#> 484 Max(planned duration, event cut) 33.18038 97
#> 485 Max(min follow-up, event cut) 33.18038 97
#> 486 Planned duration 30.00000 98
#> 487 Targeted events 31.71537 98
#> 488 Minimum follow-up 28.45155 98
#> 489 Max(planned duration, event cut) 31.71537 98
#> 490 Max(min follow-up, event cut) 31.71537 98
#> 491 Planned duration 30.00000 99
#> 492 Targeted events 36.84463 99
#> 493 Minimum follow-up 33.34436 99
#> 494 Max(planned duration, event cut) 36.84463 99
#> 495 Max(min follow-up, event cut) 36.84463 99
#> 496 Planned duration 30.00000 100
#> 497 Targeted events 36.52875 100
#> 498 Minimum follow-up 30.73208 100
#> 499 Max(planned duration, event cut) 36.52875 100
#> 500 Max(min follow-up, event cut) 36.52875 100
# }