Package index

S7 Classes and Constructors

Core S7 data structures for event tables and correlation matrices

CorrelationMatrix()

CorrelationMatrix S7 Class

EventTable()

EventTable S7 Class

as_correlation_matrix()

Convert matrix to CorrelationMatrix object

as_event_table()

Convert Data to EventTable

print.CorrelationMatrix

Print method for CorrelationMatrix

Event Table Generation

Functions for generating event count tables from clinical trial data

generate_event_table()

Generate table of event counts from ADSL and ADTTE datasets

generate_event_table_()

This function creates a table summarizing event counts based on specified hypotheses and user input data. It can handle two types of analysis: one comparing experimental groups to a common control and another analyzing the overlap of populations.

generate_event_table_cc()

This function generates a table of events for given experimental arms and a control group based on specified hypotheses.

generate_event_table_ol()

This function generates a table of events for specified populations based on the provided hypotheses.

Correlation Matrix Computation

Functions for computing correlation matrices from event data

generate_corr()

Generate correlation matrix based on event counts

generate_corr_s7()

Generate S7 CorrelationMatrix from EventTable or event data

compute_correlations()

Compute correlations from event data

gen_corr()

Convert correlation data frame to correlation matrix

Statistical Testing and Analysis

Core statistical procedures for group sequential designs

calc_seq_p()

Calculate sequential p-values for interaction/elementary hypothesis

closed_test()

Perform closed testing procedure

generate_bounds()

Compute p-value boundaries of the parametric MTP method with overall alpha spending for all hypotheses

Data Manipulation and Subsetting

Functions for working with event tables and correlation matrices

subset_event_table()

Subset EventTable by Analysis or Hypotheses

subset_correlation_matrix()

Extract correlation submatrix

Data Validation

Functions for validating and checking data integrity

check_event_data()

Check event data for correlation computation

validate_event_data_core()

Core Event Data Validation Function

validate_event_table_data()

Validate EventTable Data Format

Utility Functions

Internal utility functions for numerical computations

find_astar()

Utility function for root-finding to compute crossing probabilities with the overall alpha spending approach

find_xi()

Utility function for root-finding to compute inflation factor xi with the separate alpha spending approach

Package Information

Package documentation and tidy evaluation helpers

wpgsd wpgsd-package

wpgsd: Weighted Parametric Group Sequential Design

tidyeval enquo enquos .data := as_name as_label

Tidy eval helpers